A spitz naevus or spitz s nevus is an uncommon type of mole melanocytic naevus. All structured data from the file and property namespaces is available under the creative commons cc0 license. Spitz nevus and other spitzoid tumors in children part 1. There is debate as to whether the pscnor is an entity in its own right or whether it is a variation of a. Jan 08, 2018 melanocytic nevi with features of spitz nevi and clarksdysplastic nevi sparks nevi. Sa croissance est rapide, en quelques mois, avant une stabilisation. Files are available under licenses specified on their description page. Melanocytic spitzoid lesions include benign spitz nevus, atypical spitz. Histologically and cytologically, spitzoid melanomas share common features with spitz naevi. They usually develop on the face or limbs of young children. A spitz naevus or spitzs nevus is an uncommon type of mole melanocytic naevus. Theoretically, a spitz nevus does not removing because it is a benign grown like other moles.
A spitz nevus is a melanocytic neoplasm of epithelioid andor. Indpendently of age, sex, location, palpability, and pigmentation of the lesion, most spitz nevi tend to go through spontaneous involution over time. A type of melanocytic nevus, it affects the epidermis and dermis it is also known as an epithelioid and spindlecell nevus, and misleadingly as a benign juvenile melanoma. Pictures of skin diseases and problems spitz nevus. These lesions are termed atypical spitz nevitumors and there is currently a lack of objective criteria for.
Nevus melanociticos adquiridos pdf download 11lyv7. May involve epidermis and dermis as a confluent mass. Nevus or nevi if multiple is a nonspecific medical term for a visible, circumscribed, chronic lesion of the skin or mucosa. Spitz nevi, in their majority approximately 66% are compound 8, 510% junctional and 1220% dermal. Transepidermal elimination of nevus cells in spindle and. Discussion the occurrence of the intraoral spitz nevus is very rare, having been reported previously in the international literature only twice. Nino m, brunetti b, delfino s, panariello l, russo d. Transepidermal elimination of nevus cells of a spitz nevus was also present in one of the six cases reported by yuki et al. Jun 11, 2010 spitz nevus is an acquired melanocytic lesion, which generally develops in children and adolescents, although it is not rare in adults. Pdf a conjunctival spitz nevus is a very rare, benign melanocytic lesion, which can. A spitz nevus is often is pink and somewhat domeshaped. It was first described in 1948 but great controversy still remains today. The natural evolution of melanocytic nevi is a complex, multifactorial process involving constitutional and environmental factors. Spitz nevi can be very difficult to distinguish from melanoma, as a result treatment tends to involve excision of the nevi.
Volume 111, issue 1, januaryfebruary 2020, pages 719. These lesions are by nature benign, but their features can sometimes make. A spitz nevus is an unusual type of mole that looks similar to melanoma but isnt. Most spitz nevi occur in a persons first 20 years of life. They usually appear before the age of 20, however, they can appear on adults as well. Atypical spitzs nevus, malignant spitzs nevus, and me. Spitz naevi have also been called juvenile melanomas because they resemble malignant tumors clinically and microscopically, but the spitz naevi are actually benign. A comparative study of spitz nevus and nodular malignant. Spitz nevi usually present as solitary, pinktored plaques or nodules, but pigmented spitz nevi are also commonly. They share microscopic features of melanoma, but unlike melanoma, they are benign. In part ii of this cme, we will maintain the terminology defined in part i for purposes of continuity. The anomaly is usually referred to as benign juvenile melanoma, sometimes as spitz s nevus, and, by some histopathologists, as spindle and epithelioid cell nevus. It typically presents in childhood or adolescence as a sharply circumscribed, domeshaped, pinkred papule or plaque most commonly located on the face or lower extremities picture 1. Spitz nevi are melanocytic proliferations characterized by spindled andor.
Sabater marco v, escutia munoz b, morera faet a, roig mm, botella estrada r. Spitz nevus genetic and rare diseases information center. The name juvenile melanoma is generally no longer used as it is neither a melanoma, nor does it occur only in children. Oct 09, 2014 spitz nevus are rare, benign moles that closely resemble melanoma. Spitz nevi the plural of nevus are not harmful, but they can be difficult to differentiate from melanoma, even for experts. A 1cm raised red domeshaped nodule that suddenly appeared on the shoulder of a child.
Nevus of large spindle andor epithelioid cells spitzs. Whats more, these nevi are not always easily distinguished from melanoma even by expert dermatopathologists. However, it may resemble a malignant melanoma clinically and microscopically, so spitz naevi are often excised as a precaution. A spitz nevus is a rare type of skin mole that usually affects young people and children. It may be smooth or scaly and usually appears on the face, particularly the cheeks.
P16 expression differentiates between desmoplastic spitz nevus and. Spitz nevus is a melanocytic tumor considered a variant of the composed melanocytic nevus. Moreover, in our estimation, those designations, and variants of them, like atypical spitzs lesion, atypical dermal melanocytic lesion with features of spitzs nevus. A spitz nevus can look very much a like a serious kind of skin. It also may be called a nevus, spitz lesion, juvenile melanoma, benign juvenile melanoma, or spindle and epithelioid cell nevus of reed. Nevus spilus ns, also known as speckled lentiginous nevus, is characterized by background cafe au laitlike lentiginous melanocytic hyperplasia speckled with small, 1 to 3mm, darker foci. While these moles may develop in adults, they are more common in children and adolescents. Pdf spitz and reed nevi, also called spindle andor epithelioid cell nevi, are a special group of melanocytic.
All the histological subtleties and variations of the condition are still not fully appreciated and some of them are still being misinterpreted as those of malignant melanoma. Spitz naevi are typically domeshaped red, reddishbrown or darker bumps or blisters up to one or two centimeters in diameter. It is usually benign, but the clinical presentation and histopathology sometimes mimic melanoma. Nevus of large spindle andor epithelioid cells spitzs nevus. Spitz nevi the plural of nevus are not harmful, but they can be difficult to differentiate from melanoma. The spitz nevus is a benign melanocytic lesion with clinical and histopathological features similar to those of melanoma. An update on molecular alterations in melanocytic tumors with. This page was last edited on 22 october 2018, at 15. Clinical criteria of spitz nevus and malignant melanoma criterion spitz nevus malignant melanoma symmetry yes no, except for early lesions and the rare nodular form of melanoma diameter spitz nevus or spitz tumor is an uncommon melanocytic lesion composed of large epithelioid andor spindled cells. Melanocytes tend to spread along spitz nevus, pigmented spindle cell nevus, atypical hair follicles, blood vessels, sweat glands, and nevus, and malignant melanoma table ii.
Clinical criteria of spitz nevus and malignant melanoma criterion spitz nevus malignant melanoma symmetry yes no, except for early lesions and the rare nodular form of melanoma diameter naevus. Common terms, including mole, birthmark, and beauty mark, are used to describe nevi, but these terms do not distinguish. This is a pdf file of an unedited manuscript that has. There is debate as to whether the pscnor is an entity in its own right or whether it is a variation of a spitz naevus. Spitzoid melanoma is diagnosed on skin biopsy of an enlarging nodule. The classic spitz nevus typically is benign and has characteristic clinical and histologic features. Melanoma can have similar features to both classic and atypical spitz nevi and must be ruled out in all cases. Within the last few years, sentinel lymph node biopsy slnb has been proposed as a useful tool in the management of melanocytic neoplasms of uncertain behavior, such as the atypical spitz nevus. Although it can look like a serious form of skin cancer called melanoma, a spitz nevus lesion isnt. It is classically believed to be benign, and conservatively. A spitz nevus is typically under 1 centimeter in diameter, firm, raised, and pink or reddishbrown.
A spitz nevus is a melanocytic neoplasm of epithelioid andor spindle cells that usually appears in childhood. Spitz nevus are noncancerous skin lesions that tend to be domeshaped, red, reddishbrown or dark colored. Although it can look like a serious form of skin cancer called melanoma, a. They tend to grow quickly initially, but then stabilize or even disappear after a period of time. Many authors consider it as an unusual variant of the tumor described by sophie spitz in 1948. Spitz nevus is an acquired melanocytic lesion, which generally develops in children and adolescents, although it is not rare in adults. In this context, labels, such as spitz nevus, atypical spitz nevus, atypical spitz tumor, and spitzoid melanoma. This spitz nevus is 1 centimeter in diameter and is on a childs shoulder. Spitz nevi usually appear in children and young adults, they peak during the second and third decades of life, and are only rarely seen from the seventh decade to the ninth decade. Histologically, spitz nevus has been subdivided into. The nevus was composed of broad but laterally demarcated compound proliferation of enlarged fusiform and epithelioid melanocytes, with florid pagetoid scatter above the junction. The pigmented spindle cell naevus of reed pscnor is a variant of a compound or occasionally a junctional naevus. The anomaly is usually referred to as benign juvenile melanoma, sometimes as spitzs nevus, and, by some histopathologists, as spindle and epithelioid cell nevus. Among the various types of melanocytic nevi, spitz nevi are the most controversial due to their morphologic vicinity to melanoma.
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